SARMs – Selective Androgen Receptor Modulators
SARMs – An effective means for stimulating muscle and bone growth as you age.
SARMs Australia “SARM” is a selective androgen receptor modulator, and there are many of them.
There are those that inhibit the androgen receptor so that it doesn’t do its job as well on the nucleus of the cell.
There are those that accentuate the effect of the androgen receptor, multiplying the effect. SARMS are “selective” because they work in some cells better than in others.
Different SARMs work in different cells in the body.
The SARMs we are interested in for health and longevity and performance are the SARMs that accentuate the effect of testosterone in muscle and bone, but that don’t work in hair and skin and prostate cells throughout the body.
The objective is that you don’t experience the side effects typical of testosterone supplementation. Rather you just get the benefits.
What is an androgen receptor and how does it work with testosterone?
An androgen receptor is a protein in the cells of your body that testosterone binds to.
When testosterone binds to an androgen receptor molecule, together they move into the nucleus of the cell and they turn on genes in that cell that then tell the cell to do different things.
Dependent on what part of the body that cell is, it will do different things.
- Muscle cells produce contractile proteins = increase in muscle size, strength and mitochondrial proteins will increase energy supply to the cell.
- Bone cells promote bone growth.
- Hair cells on the body will promote hair growth.
- A sebaceous gland in the skin will boost oil production.
- Prostate cells will promote prostate growth and prostate health.
So the androgen receptor with the testosterone bound to it has effects throughout the body, and it’s important to maintain these effects throughout your life for optimal health and longevity.
MK2866 (Ostarine), particularly the muscle and bone, and it accentuates the testosterone effects in those tissues.
It’s safe to use in men and women, and it’s used in research done on people with catabolic diseases.
It is used on people with severe burns that require assistance in their tissue repair and growth, and it’s used for performance and image enhancing purposes.
Selective Androgen Receptor Modulators (SARMs) provide an alternative to using anabolic – androgenic steroids such as testosterone.
Providing the anabolic benefits typical of steroids such as testosterone (including increased muscle mass, fat loss, and bone density), MK2866 (Ostarine) minimises the unwanted androgenic side effects that coincide with steroid use such as aromatisation to estradiol, and conversion to di-hydro-testosterone (DHT).
By acting on / stimulating the androgen receptor, SARMs can provide a qualitative similar therapeutic outcome to androgen therapy without any increase in androgen levels. SARMs exert many of the same positive effects on muscle tissue as anabolic steroids like testosterone and can be administered in an injectable dosage form as well as orally. SARMs are also not as liver toxic as most oral steroids.
The anabolic effect has been measured to be virtually the same as testosterone. Bone mineral density is another benefit of using SARMs, where it has been shown to produce dose-dependent increases in bone mineral density and mechanical strength.
Benefits of MK2866 (Ostarine):
MK2866 provides the benefits of traditional anabolic /androgenic steroids such as Testosterone
- Increased lean muscle mass
- Increased fat loss
- Increased bone density
- Less side effects experienced than high dose steroids, including prostate and cardiovascular outcomes.
- Not as liver toxic, unlike most oral steroids.
- Anabolic effect noted to be similar to testosterone.